Compound Detail
CHEMBL53362
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Basic Information
| ChEMBL ID | CHEMBL53362 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XVGIZYYICTUQBN-OUKQBFOZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
4.38
ALogP
3
HBA
1
HBD
28.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 8.19 | 8.19 | 6.5 | 1 |
| Plasmodium falciparum CHEMBL364 | EC50 | 7.09 | 7.09 | 80.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | EC50 | = | 6.5 | nM | 8.19 | Concentration required for half-maximal inhibition of CpG-ODN effect on thymidin... | 10406648 |
| Plasmodium falciparum | EC50 | = | 80.7 | nM | 7.09 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 ... | 32959656 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10406648 | 10.1016/s0960-894x(99)00291-7 | NON-PROTEIN TARGET | 1 |
| 32959656 | 10.1021/acs.jmedchem.0c00858 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine