Compound Detail
CHEMBL537708
DAZOXIBEN HYDROCHLORIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL537708 |
| Name | DAZOXIBEN HYDROCHLORIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PVKDFUXBDJPRGU-UHFFFAOYSA-N |
| Parent Compound | CHEMBL267473 |
| Active Moiety | CHEMBL267473 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
4
Known Names
Molecular Properties
232.2
MW (Da)
1.66
ALogP
4
HBA
1
HBD
64.3
PSA (Ų)
0.85
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 2 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thromboxane-A synthase CHEMBL1835 | IC50 | 7.85 | 7.85 | 14.0 | 1 |
| Homo sapiens CHEMBL372 | IC50 | 5.64 | 5.64 | 2280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thromboxane-A synthase | IC50 | = | 14.0 | nM | 7.85 | Inhibitory activity against human thromboxane synthetase | 7199088 |
| Homo sapiens | IC50 | = | 2280.0 | nM | 5.64 | Inhibition of ADP-induced platelet aggregation of human PRP in the presence of p... | 1311763 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1311763 | 10.1021/jm00082a002 | Mus musculus | 8 |
| 1311763 | 10.1021/jm00082a002 | Homo sapiens | 7 |
| 1311763 | 10.1021/jm00082a002 | Rattus norvegicus | 4 |
| 7199088 | 10.1021/jm00142a005 | Thromboxane-A synthase | 1 |
Data from ChEMBL 36 via Core Engine