Compound Detail
CHEMBL5395318
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Basic Information
| ChEMBL ID | CHEMBL5395318 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SPDPFUVSKRIMJV-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
353.7
MW (Da)
2.89
ALogP
7
HBA
0
HBD
75.0
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.08
Ki 1 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | IC50 | 6.08 | 6.07 | 840.0 | 2 |
| Retinoic acid receptor RXR-alpha CHEMBL2061 | IC50 | 6.06 | 6.06 | 879.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | Ki | 6.05 | 6.05 | 900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2B | IC50 | = | 840.0 | nM | 6.08 | Negative allosteric modulation of human GluN1A/GluN2B receptor expressed in T-RE... | 36757100 |
| Retinoic acid receptor RXR-alpha | IC50 | = | 879.0 | nM | 6.06 | NR2B standard assay: NMDA receptors are ion channels that are highly permeable t... | - |
| Glutamate NMDA receptor; GRIN1/GRIN2B | IC50 | = | 879.0 | nM | 6.06 | NMDA receptor FLIPR assay: NMDA receptors are ion channels that are highly perme... | - |
| Glutamate receptor ionotropic, NMDA 2B | Ki | = | 900.0 | nM | 6.05 | Displacement of 3-(3H) 1-(azetidin-1-yl)-2-(6- (4-fluoro-3-methyl-phenyl)pyrrolo... | 36757100 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36757100 | 10.1021/acs.jmedchem.2c01916 | Glutamate NMDA receptor; GRIN1/GRIN2B | 1 |
| 36757100 | 10.1021/acs.jmedchem.2c01916 | Glutamate receptor ionotropic, NMDA 2B | 1 |
| 36757100 | 10.1021/acs.jmedchem.2c01916 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine