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Compound Detail

CHEMBL540242

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CO[C@]1(CC[C@@H](C)CO)O[C@H]2C[C@H]3[C@@H]4CC=C5C[C@@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2[C@@H]1C

Basic Information

ChEMBL ID CHEMBL540242
Phase Preclinical
Structure Type MOL
InChI Key YDURWQJGBGEELH-IHUWETLJSA-N
9
Targets
9
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

917.1
MW (Da)
-0.18
ALogP
18
HBA
10
HBD
276.1
PSA (Ų)
0.11
QED
3
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C46H76O18
MW 917.10
Aromatic Rings 0
Heavy Atoms 64
NP-Likeness 2.39

Activity Summary

IC50 9 meas. best 6.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
PANC-1
CHEMBL614139
IC50 6.09 6.09 820.0 1
SW1990
CHEMBL1075592
IC50 6.05 6.05 900.0 1
A549
CHEMBL392
IC50 6.05 6.05 890.0 1
Bel-7402
CHEMBL614279
IC50 6.04 6.04 920.0 1
BXPC-3
CHEMBL614530
IC50 6.0 6.0 1000.0 1
Capan-2
CHEMBL1075417
IC50 5.96 5.96 1100.0 1
MCF7
CHEMBL387
IC50 5.92 5.92 1200.0 1
HCT-8
CHEMBL613510
IC50 5.89 5.89 1300.0 1
A2780
CHEMBL614004
IC50 5.15 5.15 7100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine