Compound Detail
CHEMBL5407310
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5407310 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QSTZYQDJSHNEIC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
509.6
MW (Da)
3.79
ALogP
10
HBA
3
HBD
118.0
PSA (Ų)
0.29
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 7.16 | 7.16 | 68.9 | 1 |
| Serine/threonine-protein kinase PLK4 CHEMBL3788 | IC50 | 7.04 | 7.04 | 90.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 68.9 | nM | 7.16 | Inhibition of TRKA (unknown origin) using TK peptide as substrate incubated for ... | 36734825 |
| Serine/threonine-protein kinase PLK4 | IC50 | = | 90.7 | nM | 7.04 | Inhibition of PLK4 (unknown origin) incubated for 1 hr by FRET assay | 36734825 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36734825 | 10.1021/acs.jmedchem.2c02124 | Serine/threonine-protein kinase PLK4 | 1 |
| 36734825 | 10.1021/acs.jmedchem.2c02124 | High affinity nerve growth factor receptor | 1 |
| 36734825 | 10.1021/acs.jmedchem.2c02124 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine