Compound Detail
CHEMBL5409228
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Basic Information
| ChEMBL ID | CHEMBL5409228 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QPWIHEYFKTWAIQ-QPEQYQDCSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
387.3
MW (Da)
4.68
ALogP
2
HBA
3
HBD
56.9
PSA (Ų)
0.35
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 7.24 | 6.605 | 57.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 57.0 | nM | 7.24 | Inhibition of N-terminal GST-tagged human recombinant wild type TRKA (440 to end... | 37030091 |
| High affinity nerve growth factor receptor | IC50 | = | 1070.0 | nM | 5.97 | Inhibition of N-terminal GST-tagged human recombinant TRKA G595R mutant (440 to ... | 37030091 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37030091 | 10.1016/j.ejmech.2023.115291 | High affinity nerve growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine