Compound Detail
CHEMBL5411984
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Basic Information
| ChEMBL ID | CHEMBL5411984 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NJJOKGWFZQVSMR-HDICACEKSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
362.5
MW (Da)
3.50
ALogP
3
HBA
3
HBD
69.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.6
Kd 1 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-induced degradation protein 4 homolog CHEMBL5169174 | Kd | 6.3 | 6.3 | 500.0 | 1 |
| Glucose-induced degradation protein 4 homolog CHEMBL5169174 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-induced degradation protein 4 homolog | Kd | = | 500.0 | nM | 6.3 | Binding affinity to recombinant GID4 (unknown origin) assessed as dissociation c... | 38516600 |
| Glucose-induced degradation protein 4 homolog | IC50 | = | 2500.0 | nM | 5.6 | Displacement of C-terminal NanoLuc-tagged MPGLWKS peptide from N-terminal HaloTa... | 38516600 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38516600 | 10.1039/d3md00633f | Glucose-induced degradation protein 4 homolog | 3 |
Data from ChEMBL 36 via Core Engine