Compound Detail
CHEMBL5417915
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Basic Information
| ChEMBL ID | CHEMBL5417915 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HWGFCLUXIWWFKE-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
425.8
MW (Da)
3.91
ALogP
6
HBA
2
HBD
85.8
PSA (Ų)
0.58
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase SIK1 CHEMBL6082 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Serine/threonine-protein kinase SIK3 CHEMBL6149 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Serine/threonine-protein kinase SIK2 CHEMBL5699 | IC50 | 5.21 | 5.21 | 6100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase SIK1 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK... | 37094449 |
| Serine/threonine-protein kinase SIK3 | IC50 | = | 2500.0 | nM | 5.6 | Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK... | 37094449 |
| Serine/threonine-protein kinase SIK2 | IC50 | = | 6100.0 | nM | 5.21 | Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK... | 37094449 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase 4 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase 3 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase 24 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase 26 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase PAK 1 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase SIK1 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase SIK2 | 1 |
| 37094449 | 10.1016/j.ejmech.2023.115347 | Serine/threonine-protein kinase SIK3 | 1 |
Data from ChEMBL 36 via Core Engine