Compound Detail
CHEMBL5436639
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5436639 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WWJJXHPSYKGLJY-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
2.01
ALogP
8
HBA
1
HBD
90.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase SIK3 CHEMBL6149 | IC50 | 7.24 | 7.24 | 58.2 | 1 |
| Serine/threonine-protein kinase SIK2 CHEMBL5699 | IC50 | 6.81 | 6.81 | 155.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase SIK3 | IC50 | = | 58.2 | nM | 7.24 | Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate... | 38552030 |
| Serine/threonine-protein kinase SIK2 | IC50 | = | 155.9 | nM | 6.81 | Inhibition of full length human SIK2 using AMARA peptide as substrate incubated ... | 38552030 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38552030 | 10.1021/acs.jmedchem.3c02246 | Serine/threonine-protein kinase SIK1 | 1 |
| 38552030 | 10.1021/acs.jmedchem.3c02246 | Serine/threonine-protein kinase SIK2 | 1 |
| 38552030 | 10.1021/acs.jmedchem.3c02246 | Serine/threonine-protein kinase SIK3 | 1 |
Data from ChEMBL 36 via Core Engine