Compound Detail
CHEMBL55148
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL55148 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YFEZLTPSCJWVHI-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
301.1
MW (Da)
4.22
ALogP
2
HBA
0
HBD
30.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 6.38 | 6.38 | 413.0 | 1 |
| GABA-A receptor; anion channel CHEMBL2093872 | Ki | 6.38 | 6.38 | 416.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 413.0 | nM | 6.38 | Displacement of [3H]flunitrazepine binding from GABA-A central benzodiazepine re... | - |
| GABA-A receptor; anion channel | Ki | = | 416.87 | nM | 6.38 | Binding affinity towards benzodiazepine site in GABAA receptor | 11384234 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00343-0 | GABA-A receptor; anion channel | 1 |
| 11384234 | 10.1021/jm000557p | GABA-A receptor; anion channel | 1 |
| 18158201 | 10.1016/j.ejmech.2007.11.009 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine