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Assay Detail

CHEMBL877825

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Binding
Binding affinity towards benzodiazepine site in GABAA receptor
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

GABA-A receptor; anion channel (CHEMBL2093872)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.
Huang X, Liu T, Gu J, Luo X, Ji R, Cao Y, Xue H, Wong JT, Wong BL, Pei G, Jiang H, Chen K.
J Med Chem (2001) 44 : 1883 -1891
PubMed 11384234 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 42 6.40 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54341 1 9.00
CHEMBL59263 1 8.10
CHEMBL292868 1 7.92
CHEMBL59257 1 7.77
CHEMBL54878 1 7.72
CHEMBL54416 1 7.64
CHEMBL57089 1 7.64
CHEMBL299030 1 7.60
CHEMBL298805 1 7.38
CHEMBL52825 6-BROMOFLAVONE 1 7.15
CHEMBL59379 1 6.94
CHEMBL55295 1 6.93
CHEMBL55412 1 6.74
CHEMBL54512 1 6.74
CHEMBL298837 1 6.70
CHEMBL55023 1 6.70
CHEMBL56906 1 6.68
CHEMBL55147 1 6.63
CHEMBL56284 1 6.42
CHEMBL56398 1 6.38
CHEMBL55148 1 6.38
CHEMBL57045 1 6.22
CHEMBL56414 1 6.21
CHEMBL55942 1 6.15
CHEMBL55418 1 6.07
CHEMBL55550 1 6.04
CHEMBL293776 HISPIDULIN 1 6.00
CHEMBL275638 FLAVONE 2.0 1 6.00
CHEMBL301692 1 5.90
CHEMBL16171 WOGONIN 1 5.69

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54341 Ki = 1.0 nM 9.00
CHEMBL59263 Ki = 7.943 nM 8.10
CHEMBL292868 Ki = 12.02 nM 7.92
CHEMBL59257 Ki = 16.98 nM 7.77
CHEMBL54878 Ki = 19.05 nM 7.72
CHEMBL54416 Ki = 22.91 nM 7.64
CHEMBL57089 Ki = 22.91 nM 7.64
CHEMBL299030 Ki = 25.12 nM 7.60
CHEMBL298805 Ki = 41.69 nM 7.38
CHEMBL52825 6-BROMOFLAVONE Ki = 70.79 nM 7.15
CHEMBL59379 Ki = 114.82 nM 6.94
CHEMBL55295 Ki = 117.49 nM 6.93
CHEMBL55412 Ki = 181.97 nM 6.74
CHEMBL54512 Ki = 181.97 nM 6.74
CHEMBL55023 Ki = 199.53 nM 6.70
CHEMBL298837 Ki = 199.53 nM 6.70
CHEMBL56906 Ki = 208.93 nM 6.68
CHEMBL55147 Ki = 234.42 nM 6.63
CHEMBL56284 Ki = 380.19 nM 6.42
CHEMBL56398 Ki = 416.87 nM 6.38
CHEMBL55148 Ki = 416.87 nM 6.38
CHEMBL57045 Ki = 602.56 nM 6.22
CHEMBL56414 Ki = 616.6 nM 6.21
CHEMBL55942 Ki = 707.95 nM 6.15
CHEMBL55418 Ki = 851.14 nM 6.07
CHEMBL55550 Ki = 912.01 nM 6.04
CHEMBL293776 HISPIDULIN Ki = 1000.0 nM 6.00
CHEMBL275638 FLAVONE Ki = 1000.0 nM 6.00
CHEMBL301692 Ki = 1258.93 nM 5.90
CHEMBL16171 WOGONIN Ki = 2041.74 nM 5.69
CHEMBL293556 Ki = 2089.3 nM 5.68
CHEMBL54957 Ki = 2511.89 nM 5.60
CHEMBL57741 Ki = 2511.89 nM 5.60
CHEMBL117 CHRYSIN Ki = 3019.95 nM 5.52
CHEMBL28 APIGENIN Ki = 3019.95 nM 5.52
CHEMBL54340 Ki = 3548.13 nM 5.45
CHEMBL53738 Ki = 3630.78 nM 5.44
CHEMBL8260 BAICALEIN Ki = 5623.41 nM 5.25
CHEMBL59589 Ki = 7943.28 nM 5.10
CHEMBL57171 Ki = 7943.28 nM 5.10
CHEMBL55415 SCUTELLAREIN Ki = 12022.64 nM 4.92
CHEMBL485818 BAICALIN Ki = 77624.71 nM 4.11