Compound Detail
CHEMBL56906
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Basic Information
| ChEMBL ID | CHEMBL56906 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GXUSNZYZTBJMIT-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
346.1
MW (Da)
4.13
ALogP
4
HBA
0
HBD
73.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 6.68 | 6.68 | 208.0 | 2 |
| GABA-A receptor; anion channel CHEMBL2093872 | Ki | 6.68 | 6.68 | 208.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 208.0 | nM | 6.68 | Displacement of [3H]flunitrazepine binding from GABA-A central benzodiazepine re... | - |
| GABA-A receptor; anion channel | Ki | = | 208.0 | nM | 6.68 | Inhibition of [3H]flunitrazepam [3H]FNZ) binding to GABA-A Benzodiazepine recept... | - |
| GABA-A receptor; anion channel | Ki | = | 208.93 | nM | 6.68 | Binding affinity towards benzodiazepine site in GABAA receptor | 11384234 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00343-0 | GABA-A receptor; anion channel | 1 |
| - | 10.1016/S0960-894X(97)00020-6 | GABA-A receptor; anion channel | 1 |
| 11384234 | 10.1021/jm000557p | GABA-A receptor; anion channel | 1 |
| 18158201 | 10.1016/j.ejmech.2007.11.009 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine