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Compound Detail

CHEMBL554232

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Cl.O=C(NCCNCC1COc2ccccc2O1)c1ccco1

Basic Information

ChEMBL ID CHEMBL554232
Phase Preclinical
Structure Type MOL
InChI Key XDTZUMJFDHODRO-UHFFFAOYSA-N
Parent Compound CHEMBL1195303
Active Moiety CHEMBL1195303
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

302.3
MW (Da)
1.44
ALogP
5
HBA
2
HBD
72.7
PSA (Ų)
0.79
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H19ClN2O4
MW 338.79
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.92

Activity Summary

Kd 2 meas. best 7.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 7.19 7.19 64.6 1
Rattus norvegicus
CHEMBL376
Kd 5.85 5.85 1412.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2863379 10.1021/jm00147a042 Adrenergic receptor alpha-1 1
2863379 10.1021/jm00147a042 Rattus norvegicus 1
2863379 10.1021/jm00147a042 Unchecked 1

Data from ChEMBL 36 via Core Engine