Compound Detail
CHEMBL5558254
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Basic Information
| ChEMBL ID | CHEMBL5558254 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LMMXMJJQNDXLSR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
2.60
ALogP
8
HBA
4
HBD
141.8
PSA (Ų)
0.36
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK4 CHEMBL3788 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK4 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of PLK4 (unknown origin) | 38199166 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38199166 | 10.1016/j.ejmech.2023.116115 | Serine/threonine-protein kinase PLK4 | 1 |
Data from ChEMBL 36 via Core Engine