Assay Detail
Binding
CHEMBL5513247
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Inhibition of PLK4 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK4 (CHEMBL3788) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic potential of targeting polo-like kinase 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.39 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 8.38 |
| CHEMBL5565760 | — | — | 1 | 7.95 |
| CHEMBL5173724 | — | — | 1 | 7.65 |
| CHEMBL2407901 | — | — | 1 | 7.60 |
| CHEMBL5558254 | — | — | 1 | 7.57 |
| CHEMBL1908397 | KW-2449 | 1.0 | 1 | 7.28 |
| CHEMBL2407902 | — | — | 1 | 7.00 |
| CHEMBL5559158 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289926 | AXITINIB | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5565760 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5173724 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL2407901 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5558254 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1908397 | KW-2449 | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL2407902 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5559158 | — | IC50 | = | 2101.0 | nM | 5.68 |