Compound Detail
CHEMBL5565760
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Basic Information
| ChEMBL ID | CHEMBL5565760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XVEHWADUNRICSP-JXMROGBWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
370.5
MW (Da)
3.83
ALogP
5
HBA
2
HBD
83.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK4 CHEMBL3788 | IC50 | 7.95 | 7.95 | 11.2 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK4 | IC50 | = | 11.2 | nM | 7.95 | Inhibition of PLK4 (unknown origin) | 38199166 |
| Unchecked | IC50 | = | 60.0 | nM | 7.22 | Antiproliferative activity against human TNBC cells assessed as reduction in cel... | 38199166 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38199166 | 10.1016/j.ejmech.2023.116115 | Serine/threonine-protein kinase PLK4 | 1 |
| 38199166 | 10.1016/j.ejmech.2023.116115 | Unchecked | 1 |
| 38199166 | 10.1016/j.ejmech.2023.116115 | MDA-MB-468 | 1 |
Data from ChEMBL 36 via Core Engine