Compound Detail
CHEMBL5562279
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Basic Information
| ChEMBL ID | CHEMBL5562279 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KAPMKULMYGROOA-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
364.4
MW (Da)
3.03
ALogP
6
HBA
2
HBD
96.3
PSA (Ų)
0.67
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.0
Kd 1 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
| BDNF/NT-3 growth factors receptor CHEMBL4898 | Kd | 7.44 | 7.44 | 36.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 10.0 | nM | 8.0 | Inhibition of CSF1R (unknown origin) | 38330850 |
| BDNF/NT-3 growth factors receptor | Kd | = | 36.0 | nM | 7.44 | Binding affinity to TRKB (unknown origin) receptor assessed as dissociation cons... | 38330850 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38330850 | 10.1016/j.bmc.2024.117628 | BDNF/NT-3 growth factors receptor | 1 |
| 38330850 | 10.1016/j.bmc.2024.117628 | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine