Assay Detail
Binding
CHEMBL5524445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF1R (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Colony Stimulating Factor-1 Receptor: An emerging target for neuroinflammation PET imaging and AD therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.32 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398509 | — | — | 1 | 9.11 |
| CHEMBL4227505 | SOTULETINIB | 2.0 | 1 | 9.00 |
| CHEMBL5561172 | — | — | 1 | 8.22 |
| CHEMBL481806 | — | — | 1 | 8.22 |
| CHEMBL5562279 | — | — | 1 | 8.00 |
| CHEMBL4474690 | — | — | 1 | 7.96 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398509 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4227505 | SOTULETINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5561172 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL481806 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5562279 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4474690 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 20.0 | nM | 7.70 |