Compound Detail
CHEMBL5566124
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Basic Information
| ChEMBL ID | CHEMBL5566124 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LOOBUNKZIGSHBZ-LBPRGKRZSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
433.9
MW (Da)
1.74
ALogP
7
HBA
2
HBD
119.0
PSA (Ų)
0.67
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ghrelin O-acyltransferase CHEMBL3588729 | IC50 | 7.22 | 7.19 | 60.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ghrelin O-acyltransferase | IC50 | = | 60.0 | nM | 7.22 | Inhibition of GOAT (unknown origin) | 38621327 |
| Ghrelin O-acyltransferase | IC50 | = | 68.9 | nM | 7.16 | Human GOAT Enzymatic Assay: Prepare test compounds in DMSO to make up a 0.2 mM s... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38621327 | 10.1016/j.ejmech.2024.116408 | Ghrelin O-acyltransferase | 1 |
Data from ChEMBL 36 via Core Engine