Compound Detail
CHEMBL5570898
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Basic Information
| ChEMBL ID | CHEMBL5570898 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BYEHKJQZHIERMZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
378.5
MW (Da)
1.93
ALogP
6
HBA
1
HBD
74.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
13
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5B CHEMBL3774295 | IC50 | 6.66 | 6.66 | 218.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5B | IC50 | = | 218.0 | nM | 6.66 | Inhibition of KDM5B (unknown origin) incubated for 2 hrs by Alphascreen assay | 38168630 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38168630 | 10.1016/j.bmc.2023.117579 | Unchecked | 5 |
| 38168630 | 10.1016/j.bmc.2023.117579 | Lysine-specific demethylase 5B | 1 |
| 38168630 | 10.1016/j.bmc.2023.117579 | ADMET | 1 |
| 38168630 | 10.1016/j.bmc.2023.117579 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine