Assay Detail
Binding
CHEMBL5550275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM5B (unknown origin) incubated for 2 hrs by Alphascreen assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.96 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569973 | — | — | 1 | 8.70 |
| CHEMBL3787669 | — | — | 1 | 8.65 |
| CHEMBL5568891 | — | — | 1 | 8.52 |
| CHEMBL5592899 | — | — | 1 | 8.20 |
| CHEMBL5564929 | — | — | 1 | 8.16 |
| CHEMBL5569731 | — | — | 1 | 8.07 |
| CHEMBL3786593 | — | — | 1 | 6.68 |
| CHEMBL5570898 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569973 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL3787669 | — | IC50 | = | 2.23 | nM | 8.65 |
| CHEMBL5568891 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL5592899 | — | IC50 | = | 6.32 | nM | 8.20 |
| CHEMBL5564929 | — | IC50 | = | 6.94 | nM | 8.16 |
| CHEMBL5569731 | — | IC50 | = | 8.42 | nM | 8.07 |
| CHEMBL3786593 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL5570898 | — | IC50 | = | 218.0 | nM | 6.66 |