Compound Detail
CHEMBL5592899
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Basic Information
| ChEMBL ID | CHEMBL5592899 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLDLWYWYZLUVBY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
1.06
ALogP
5
HBA
2
HBD
85.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5B CHEMBL3774295 | IC50 | 8.2 | 8.2 | 6.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5B | IC50 | = | 6.32 | nM | 8.2 | Inhibition of KDM5B (unknown origin) incubated for 2 hrs by Alphascreen assay | 38168630 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38168630 | 10.1016/j.bmc.2023.117579 | Lysine-specific demethylase 5B | 2 |
Data from ChEMBL 36 via Core Engine