Compound Detail
CHEMBL5574538
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Basic Information
| ChEMBL ID | CHEMBL5574538 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UXIHCIYDMGYKSF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
282.4
MW (Da)
1.29
ALogP
6
HBA
2
HBD
72.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.56
Kd 1 meas. best 7.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 7.56 | 7.56 | 27.7 | 1 |
| Mitogen-activated protein kinase 10 CHEMBL2637 | Kd | 7.34 | 7.34 | 46.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 | IC50 | = | 27.7 | nM | 7.56 | Inhibition of JNK3 (unknown origin) | 37722288 |
| Mitogen-activated protein kinase 10 | Kd | = | 46.0 | nM | 7.34 | Binding affinity to JNK3 (unknown origin) assessed as dissociation constant by H... | 37722288 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37722288 | 10.1016/j.ejmech.2023.115817 | Mitogen-activated protein kinase 10 | 2 |
Data from ChEMBL 36 via Core Engine