Compound Detail
CHEMBL5591383
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Basic Information
| ChEMBL ID | CHEMBL5591383 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DDAJBUQQWFXHDM-UUYKTWPLSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
311.3
MW (Da)
1.12
ALogP
4
HBA
4
HBD
123.9
PSA (Ų)
0.41
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.05
Ki 1 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 2 CHEMBL3683 | Ki | 6.89 | 6.89 | 130.0 | 1 |
| Hippocampus CHEMBL613631 | EC50 | 6.05 | 6.05 | 887.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 2 | Ki | = | 130.0 | nM | 6.89 | Displacement of [3H]-kainic acid from GluR6 (unknown origin) expressed in Sf9 ce... | 39133077 |
| Hippocampus | EC50 | = | 887.0 | nM | 6.05 | Reduction in CA1 spike amplitude in Wistar rat hippocampal slices after 20 mins ... | 39133077 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Glutamate receptor ionotropic, kainate 2 | 1 |
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Hippocampus | 1 |
Data from ChEMBL 36 via Core Engine