Assay Detail
Functional
CHEMBL5579293
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Reduction in CA1 spike amplitude in Wistar rat hippocampal slices after 20 mins of toxin administration
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.04 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232313 | DOMOIC ACID | — | 1 | 6.64 |
| CHEMBL5591383 | — | — | 1 | 6.05 |
| CHEMBL5592585 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232313 | DOMOIC ACID | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL5591383 | — | EC50 | = | 887.0 | nM | 6.05 |
| CHEMBL5592585 | — | EC50 | = | 3712.0 | nM | 5.43 |