Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL560579

PROPICONAZOLE
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCCC1COC(Cn2cncn2)(c2ccc(Cl)cc2Cl)O1

Basic Information

ChEMBL ID CHEMBL560579
Name PROPICONAZOLE
Phase Preclinical
Structure Type MOL
InChI Key STJLVHWMYQXCPB-UHFFFAOYSA-N
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
19
Publications
0
Known Names

Molecular Properties

342.2
MW (Da)
3.65
ALogP
5
HBA
0
HBD
49.2
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C15H17Cl2N3O2
MW 342.23
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.17

Activity Summary

EC50 1 meas. best 7.39
IC50 1 meas. best 5.98

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 7.39 7.39 41.0 1
Cytochrome P450 3A4
CHEMBL340
IC50 5.98 5.98 1039.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 41.0 nM 7.39 PUBCHEM_BIOASSAY: Luminescence Cell-Based/Microorganism Primary HTS to Identify ... -
Cytochrome P450 3A4 IC50 = 1039.92 nM 5.98 Inhibition of CYP3A4 19128860

Literature References

PubMed DOI Target Context # Activities
- 10.1016/j.cropro.2006.02.001 Colletotrichum truncatum 51
- 10.1016/j.cropro.2006.07.001 Monilinia fructicola 15
- 10.1016/j.cropro.2006.06.008 Fusarium odoratissimum 5
- 10.1584/jpestics.G11-41 Rhizoctonia solani 4
- 10.1016/j.cropro.2006.06.008 Musa acuminata AAA Group 2
- 10.1016/j.cropro.2006.02.001 Capsicum annuum 1
- 10.1584/jpestics.G11-41 Sclerotinia sclerotiorum 1
- 10.1584/jpestics.G11-41 Fusarium graminearum 1
- 10.1584/jpestics.G11-41 Botrytis cinerea 1
- 10.1584/jpestics.G11-41 Phytophthora capsici 1
- 10.1584/jpestics.G11-41 Alternaria alternata 1
- 10.1584/jpestics.G11-41 Ustilaginoidea 1
- 10.1016/j.cropro.2006.02.001 Puccinia allii 1
19128860 10.1016/j.ejmech.2008.12.004 Cytochrome P450 3A4 1
20014765 10.1021/jf902168d Alternaria solani 1
20014765 10.1021/jf902168d Mycosphaerella arachidis 1
20014765 10.1021/jf902168d Botryosphaeria berengeriana 1
20014765 10.1021/jf902168d Fusarium graminearum 1
20014765 10.1021/jf902168d Botrytis cinerea 1

Data from ChEMBL 36 via Core Engine