Compound Detail
CHEMBL5633822
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Basic Information
| ChEMBL ID | CHEMBL5633822 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LUBCTIQAZDQPJR-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
273.4
MW (Da)
2.52
ALogP
3
HBA
3
HBD
63.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 6 CHEMBL1275221 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Protein arginine N-methyltransferase 8 CHEMBL3108648 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Protein arginine N-methyltransferase 1 CHEMBL5524 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Histone-arginine methyltransferase CARM1 CHEMBL5406 | IC50 | 7.08 | 7.08 | 83.0 | 1 |
| Protein arginine N-methyltransferase 3 CHEMBL5891 | IC50 | 6.92 | 6.92 | 119.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 6 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of PRMT6 (unknown origin) | 37597437 |
| Protein arginine N-methyltransferase 8 | IC50 | = | 5.0 | nM | 8.3 | Inhibition of PRMT8 (unknown origin) | 37597437 |
| Protein arginine N-methyltransferase 1 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of PRMT1 (unknown origin) | 37597437 |
| Histone-arginine methyltransferase CARM1 | IC50 | = | 83.0 | nM | 7.08 | Inhibition of PRMT4 (unknown origin) | 37597437 |
| Protein arginine N-methyltransferase 3 | IC50 | = | 119.0 | nM | 6.92 | Inhibition of PRMT3 (unknown origin) | 37597437 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37597437 | 10.1016/j.ejmech.2023.115713 | Protein arginine N-methyltransferase 3 | 1 |
| 37597437 | 10.1016/j.ejmech.2023.115713 | Histone-arginine methyltransferase CARM1 | 1 |
| 37597437 | 10.1016/j.ejmech.2023.115713 | Protein arginine N-methyltransferase 6 | 1 |
| 37597437 | 10.1016/j.ejmech.2023.115713 | Protein arginine N-methyltransferase 8 | 1 |
| 37597437 | 10.1016/j.ejmech.2023.115713 | Protein arginine N-methyltransferase 1 | 1 |
Data from ChEMBL 36 via Core Engine