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Compound Detail

CHEMBL564658

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Cc1nc([N+](=O)[O-])cn1CC(=O)Nc1ccc(C#N)cc1

Basic Information

ChEMBL ID CHEMBL564658
Phase Preclinical
Structure Type MOL
InChI Key XLIRYOIPMVJXGL-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

285.3
MW (Da)
1.61
ALogP
6
HBA
1
HBD
113.8
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H11N5O3
MW 285.26
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -2.69

Activity Summary

IC50 3 meas. best 4.95

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 4.95 4.95 11250.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 4.85 4.85 14200.0 1
Entamoeba histolytica
CHEMBL612853
IC50 4.38 4.38 41230.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19208443 10.1016/j.ejmech.2009.01.005 Unchecked 3
19208443 10.1016/j.ejmech.2009.01.005 Trichomonas vaginalis 2
19208443 10.1016/j.ejmech.2009.01.005 Giardia intestinalis 2
19208443 10.1016/j.ejmech.2009.01.005 MDCK 1
19208443 10.1016/j.ejmech.2009.01.005 Entamoeba histolytica 1

Data from ChEMBL 36 via Core Engine