Compound Detail
CHEMBL5661876
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5661876 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DTSBCBAYOGVOSD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
322.4
MW (Da)
4.84
ALogP
3
HBA
1
HBD
54.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 7.14 | 7.14 | 73.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 73.0 | nM | 7.14 | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated fo... | 24900173 |
| Unchecked | IC50 | = | 2700.0 | nM | 5.57 | Inhibition of Akt phosphorylation at S473 residue (unknown origin) by cell based... | 24900173 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900173 | 10.1021/ml900028r | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 24900173 | 10.1021/ml900028r | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine