Compound Detail
CHEMBL5661894
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Basic Information
| ChEMBL ID | CHEMBL5661894 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KTYWTELNCXVBSK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
283.3
MW (Da)
4.36
ALogP
3
HBA
0
HBD
38.7
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 260.0 | nM | 6.58 | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated fo... | 24900173 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900173 | 10.1021/ml900028r | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 24900173 | 10.1021/ml900028r | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine