Compound Detail
CHEMBL566253
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL566253 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FKNPFDGOZHGKTD-OAHLLOKOSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
397.4
MW (Da)
4.49
ALogP
7
HBA
0
HBD
74.4
PSA (Ų)
0.44
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.63 | 6.63 | 236.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 5.05 | 4.9 | 8900.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 236.0 | nM | 6.63 | Inhibition of c-Met by HTRF assay | 19819693 |
| Cytochrome P450 3A4 | IC50 | = | 8900.0 | nM | 5.05 | Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPH | 19819693 |
| Cytochrome P450 3A4 | IC50 | = | 18000.0 | nM | 4.75 | Inhibition of human CYP3A4 | 19819693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19819693 | 10.1016/j.bmcl.2009.09.096 | Cytochrome P450 3A4 | 3 |
| 19819693 | 10.1016/j.bmcl.2009.09.096 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine