Compound Detail
CHEMBL568759
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CCN1CCN(c2ccc3c(c2)ncn3-c2ccnc(N[C@@H](C)[C@@H]3CN(C(=O)Nc4cccc5ccccc45)CCN3C)n2)C1=O
Basic Information
| ChEMBL ID | CHEMBL568759 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WAKMBOPGTZEJIO-JHOBJCJYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
618.8
MW (Da)
4.88
ALogP
8
HBA
2
HBD
114.8
PSA (Ų)
0.27
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 9.4 | 9.4 | 0.4 | 1 |
| Jurkat CHEMBL397 | IC50 | 7.38 | 7.38 | 42.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | IC50 | = | 0.4 | nM | 9.4 | Inhibition of Lck | 19674899 |
| Jurkat | IC50 | = | 42.0 | nM | 7.38 | Inhibition of antigen-stimulated IL-2 production in human Jurkat cells expressin... | 19674899 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19674899 | 10.1016/j.bmcl.2009.07.102 | Tyrosine-protein kinase Lck | 1 |
| 19674899 | 10.1016/j.bmcl.2009.07.102 | Jurkat | 1 |
Data from ChEMBL 36 via Core Engine