Assay Detail
Functional
CHEMBL1049047
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Inhibition of antigen-stimulated IL-2 production in human Jurkat cells expressing MART-1 antigen specific TCR
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Disubstituted pyrimidines as Lck inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.91 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572197 | — | — | 1 | 8.10 |
| CHEMBL566284 | — | — | 1 | 7.80 |
| CHEMBL569240 | — | — | 1 | 7.71 |
| CHEMBL568759 | — | — | 1 | 7.38 |
| CHEMBL567881 | — | — | 1 | 7.24 |
| CHEMBL585573 | — | — | 1 | 7.07 |
| CHEMBL584721 | — | — | 1 | 7.01 |
| CHEMBL567029 | — | — | 1 | 6.96 |
| CHEMBL566813 | — | — | 1 | 6.96 |
| CHEMBL565933 | — | — | 1 | 6.96 |
| CHEMBL566582 | — | — | 1 | 6.89 |
| CHEMBL569496 | — | — | 1 | 6.81 |
| CHEMBL566373 | — | — | 1 | 6.78 |
| CHEMBL569052 | — | — | 2 | 6.44 |
| CHEMBL568762 | — | — | 1 | 6.27 |
| CHEMBL565263 | — | — | 1 | 6.26 |
| CHEMBL566507 | — | — | 1 | 6.07 |
| CHEMBL568326 | — | — | 1 | 5.68 |
| CHEMBL585574 | — | — | 1 | - |
| CHEMBL568763 | — | — | 1 | - |
| CHEMBL567592 | — | — | 1 | - |
| CHEMBL577469 | — | — | 1 | - |
| CHEMBL569250 | — | — | 1 | - |
| CHEMBL568543 | — | — | 1 | - |
| CHEMBL568542 | — | — | 1 | - |
| CHEMBL568101 | — | — | 1 | - |
| CHEMBL572095 | — | — | 1 | - |
| CHEMBL572079 | — | — | 1 | - |
| CHEMBL572200 | — | — | 1 | - |
| CHEMBL572199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572197 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL566284 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL569240 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL568759 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL567881 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL585573 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL584721 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL567029 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL565933 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL566813 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL566582 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL569496 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL566373 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL569052 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL568762 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL565263 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL566507 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL568326 | — | IC50 | = | 2073.0 | nM | 5.68 |
| CHEMBL568763 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL585574 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL567592 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL577469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL569250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL568543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL568542 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL568101 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL572095 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL572079 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL572200 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL572199 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL569052 | — | IC50 | > | 1000.0 | nM | - |