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Compound Detail

CHEMBL570535

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Cc1nc([N+](=O)[O-])cn1CC(=O)Nc1cccc(C(F)(F)F)c1

Basic Information

ChEMBL ID CHEMBL570535
Phase Preclinical
Structure Type MOL
InChI Key QMTPUVZLHFTUES-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

328.2
MW (Da)
2.76
ALogP
5
HBA
1
HBD
90.1
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H11F3N4O3
MW 328.25
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -2.60

Activity Summary

IC50 3 meas. best 4.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Entamoeba histolytica
CHEMBL612853
IC50 4.54 4.54 29080.0 1
Giardia intestinalis
CHEMBL612652
IC50 4.42 4.42 37590.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 4.17 4.17 67430.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19208443 10.1016/j.ejmech.2009.01.005 Unchecked 3
19208443 10.1016/j.ejmech.2009.01.005 Trichomonas vaginalis 1
19208443 10.1016/j.ejmech.2009.01.005 MDCK 1
19208443 10.1016/j.ejmech.2009.01.005 Giardia intestinalis 1
19208443 10.1016/j.ejmech.2009.01.005 Entamoeba histolytica 1

Data from ChEMBL 36 via Core Engine