Compound Detail
CHEMBL571495
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Basic Information
| ChEMBL ID | CHEMBL571495 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SQSHBJWLWQSASB-DOFZRALJSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
371.6
MW (Da)
6.28
ALogP
2
HBA
0
HBD
37.4
PSA (Ų)
0.19
QED
1
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monoglyceride lipase CHEMBL4191 | IC50 | 5.95 | 5.95 | 1122.0 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 5.66 | 5.66 | 2187.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monoglyceride lipase | IC50 | = | 1122.02 | nM | 5.95 | Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid ... | 19883085 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 2187.76 | nM | 5.66 | Inhibition of human recombinant FAAH-maltose binding protein | 19883085 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19883085 | 10.1021/jm901323s | Fatty-acid amide hydrolase 1 | 1 |
| 19883085 | 10.1021/jm901323s | Monoglyceride lipase | 1 |
| 19883085 | 10.1021/jm901323s | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine