Compound Detail
CHEMBL5747283
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5747283 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FUNZVDGKJVAOOJ-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
392.4
MW (Da)
2.88
ALogP
8
HBA
1
HBD
86.5
PSA (Ų)
0.56
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polycomb protein EED CHEMBL2189117 | IC50 | 8.62 | 8.4267 | 2.4 | 3 |
| EZH2/SUZ12/EED complex CHEMBL3137286 | IC50 | 8.62 | 8.4267 | 2.4 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| EZH2/SUZ12/EED complex | IC50 | = | 2.4 | nM | 8.62 | AlphaScreen: To assess the compounds potency in the EED-H3K27Me3 competition bin... | - |
| Polycomb protein EED | IC50 | = | 2.4 | nM | 8.62 | EED-H3K27Me3 Peptide Competition Binding Assay by AlphaScreen: To assess the com... | - |
| EZH2/SUZ12/EED complex | IC50 | = | 4.3 | nM | 8.37 | ELISA Assay: Cell lysates were transferred to the wells of a 384-well plate and ... | - |
| Polycomb protein EED | IC50 | = | 4.3 | nM | 8.37 | ELISA (H3K27 Methylation) Assay: Representative compounds of the present disclos... | - |
| EZH2/SUZ12/EED complex | IC50 | = | 5.1 | nM | 8.29 | LC-MS Assay: Representative compounds of the present disclosure were serially an... | - |
| Polycomb protein EED | IC50 | = | 5.1 | nM | 8.29 | EED LC-MS Assay: Representative compounds of the present disclosure were seriall... | - |
Data from ChEMBL 36 via Core Engine