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Compound Detail

CHEMBL575796

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COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCCC(C)C)CC2)c(OC)c1

Basic Information

ChEMBL ID CHEMBL575796
Phase Preclinical
Structure Type MOL
InChI Key GZEKBYKHVMXDNP-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

593.8
MW (Da)
4.03
ALogP
7
HBA
1
HBD
105.2
PSA (Ų)
0.40
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H43N3O6S2
MW 593.81
Aromatic Rings 2
Heavy Atoms 40
NP-Likeness -0.97

Activity Summary

Ki 3 meas. best 7.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1b receptor
CHEMBL2659
Ki 7.57 7.57 27.0 1
Vasopressin V1b receptor
CHEMBL1921
Ki 7.46 7.46 35.0 1
Vasopressin V1a receptor
CHEMBL1889
Ki 6.02 6.02 947.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19800231 10.1016/j.bmcl.2009.09.050 Vasopressin V1b receptor 2
19800231 10.1016/j.bmcl.2009.09.050 Vasopressin V1a receptor 1

Data from ChEMBL 36 via Core Engine