Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL575986

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
O=S(=O)(CCC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)cc1)N1CCC(NCc2cccs2)CC1

Basic Information

ChEMBL ID CHEMBL575986
Phase Preclinical
Structure Type MOL
InChI Key ZGLCFCFZNBHFMB-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

594.2
MW (Da)
4.89
ALogP
6
HBA
1
HBD
86.8
PSA (Ų)
0.38
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H32ClN3O4S3
MW 594.22
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -1.71

Activity Summary

Ki 3 meas. best 6.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1b receptor
CHEMBL1921
Ki 6.22 6.22 600.0 1
Vasopressin V1b receptor
CHEMBL2659
Ki 6.09 6.09 813.0 1
Vasopressin V1a receptor
CHEMBL1889
Ki 5.3 5.3 4963.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19800231 10.1016/j.bmcl.2009.09.050 Vasopressin V1b receptor 2
19800231 10.1016/j.bmcl.2009.09.050 Vasopressin V1a receptor 1

Data from ChEMBL 36 via Core Engine