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Compound Detail

CHEMBL5772902

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Cc1cnc(-c2cc(OCC3(C)CCOC3)cc(C(=O)N[C@@H](C)c3cnc(C(F)(F)F)nc3)c2)s1

Basic Information

ChEMBL ID CHEMBL5772902
Phase Preclinical
Structure Type MOL
InChI Key FUZHKJYNGBDBHI-NGMICRHFSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

506.6
MW (Da)
5.22
ALogP
7
HBA
1
HBD
86.2
PSA (Ų)
0.47
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H25F3N4O3S
MW 506.55
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.18

Activity Summary

IC50 4 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2X purinoceptor 3
CHEMBL2998
IC50 8.4 8.4 4.0 2
P2X purinoceptor 2
CHEMBL2531
IC50 6.88 6.88 132.0 1
P2X2/P2X3 heterotrimeric receptor
CHEMBL3831281
IC50 6.88 6.88 132.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine