Compound Detail
CHEMBL5774346
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Basic Information
| ChEMBL ID | CHEMBL5774346 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTDFGWDIWYDCOD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
456.9
MW (Da)
5.18
ALogP
7
HBA
1
HBD
67.6
PSA (Ų)
0.40
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | IC50 | 8.38 | 8.38 | 4.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 4.2 | nM | 8.38 | Proximity Ligation Assay: Isolated cardiomyocytes were washed twice in PBS at ro... | - |
Data from ChEMBL 36 via Core Engine