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Compound Detail

CHEMBL577816

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O=C(OCC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)cc1)N1CCC(NCc2cccs2)CC1

Basic Information

ChEMBL ID CHEMBL577816
Phase Preclinical
Structure Type MOL
InChI Key WYNIZCUIDXTOCU-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

560.1
MW (Da)
5.30
ALogP
6
HBA
1
HBD
79.0
PSA (Ų)
0.42
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H30ClN3O4S2
MW 560.14
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -1.64

Activity Summary

Ki 3 meas. best 6.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1b receptor
CHEMBL1921
Ki 6.94 6.94 114.0 1
Vasopressin V1b receptor
CHEMBL2659
Ki 5.35 5.35 4456.0 1
Vasopressin V1a receptor
CHEMBL1889
Ki 5.21 5.21 6164.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19800231 10.1016/j.bmcl.2009.09.050 Vasopressin V1b receptor 2
19800231 10.1016/j.bmcl.2009.09.050 Vasopressin V1a receptor 1

Data from ChEMBL 36 via Core Engine