Compound Detail
CHEMBL5798924
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Basic Information
| ChEMBL ID | CHEMBL5798924 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BXCHTGZYZMAJHD-WDEREUQCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
417.9
MW (Da)
3.79
ALogP
7
HBA
3
HBD
98.8
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 8.47 | 8.47 | 3.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | IC50 | = | 0.6 | nM | 9.22 | Measurement of Inhibitory Activity Against JAK3 and BTK Enzymes: JAK3 and BTK ki... | - |
| Tyrosine-protein kinase BTK | IC50 | = | 3.4 | nM | 8.47 | Measurement of Inhibitory Activity Against JAK3 and BTK Enzymes: JAK3 and BTK ki... | - |
Data from ChEMBL 36 via Core Engine