Compound Detail
CHEMBL5812828
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Basic Information
| ChEMBL ID | CHEMBL5812828 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JSNLQEVTILZGHC-LXFQVNARSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
608.6
MW (Da)
2.75
ALogP
8
HBA
4
HBD
150.6
PSA (Ų)
0.22
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.78 | 8.78 | 1.7 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.78 | 8.78 | 1.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1.67 | nM | 8.78 | GILZ gene assays: HUT78 cells were cultured in IMEM plus 20% heat inactivated FB... | - |
| Glucocorticoid receptor | IC50 | = | 1.67 | nM | 8.78 | Glucocorticoid Receptor Competitor Assay: The potency of binding to gucocorticoi... | - |
Data from ChEMBL 36 via Core Engine