Compound Detail
CHEMBL5817555
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5817555 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ITEIGISUTJIFPA-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
366.9
MW (Da)
5.09
ALogP
5
HBA
0
HBD
52.3
PSA (Ų)
0.46
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | IC50 | 8.52 | 8.52 | 3.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of Recombinant PDE2A: The DNA encoding PDE2A (NM002599) was cloned an... | - |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 3.0 | nM | 8.52 | Proximity Ligation Assay: Isolated cardiomyocytes were washed twice in PBS at ro... | - |
Data from ChEMBL 36 via Core Engine