Compound Detail
CHEMBL5820678
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Basic Information
| ChEMBL ID | CHEMBL5820678 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RTYCSOHJUAWUAK-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
399.4
MW (Da)
2.72
ALogP
5
HBA
3
HBD
135.4
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDK8/Cyclin C CHEMBL3038474 | IC50 | 8.05 | 8.05 | 8.9 | 1 |
| Cyclin-C/Cyclin-dependent kinase 19 CHEMBL3883323 | IC50 | 7.68 | 7.68 | 20.7 | 1 |
| Serine/threonine-protein kinase haspin CHEMBL1075163 | IC50 | 5.56 | 5.56 | 2740.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CDK8/Cyclin C | IC50 | = | 8.94 | nM | 8.05 | CDK8/Cyclin C Binding Assay: The binding assay relies on the LanthaScreen Eu-Ki... | - |
| Cyclin-C/Cyclin-dependent kinase 19 | IC50 | = | 20.7 | nM | 7.68 | CDK19/Cyclin C Binding Assay: The binding assay relies on the LanthaScreen Eu-K... | - |
| Serine/threonine-protein kinase haspin | IC50 | = | 2740.0 | nM | 5.56 | Haspin Kinase Assay: The kinase assay relies on ADP-GloKM biochemical kinase ass... | - |
Data from ChEMBL 36 via Core Engine