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Compound Detail

CHEMBL5856962

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COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc(C(=O)NC4CCN(C5COC5)CC4)[nH]c3C(C)C)c12

Basic Information

ChEMBL ID CHEMBL5856962
Phase Preclinical
Structure Type MOL
InChI Key RIACYICSJAHABL-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

597.7
MW (Da)
5.41
ALogP
8
HBA
3
HBD
134.2
PSA (Ų)
0.23
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H39N7O4
MW 597.72
Aromatic Rings 5
Heavy Atoms 44
NP-Likeness -0.55

Activity Summary

Ki 6 meas. best 8.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bromodomain-containing protein 3
CHEMBL1795186
Ki 8.66 8.255 2.2 2
Bromodomain-containing protein 2
CHEMBL1293289
Ki 8.19 8.1 6.5 3
Bromodomain-containing protein 4
CHEMBL1163125
Ki 7.68 7.68 21.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine