Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5857824

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C=CC(=O)Nc1cc(N2CCC(N(C)C3CC3)CC2)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5857824
Phase Preclinical
Structure Type MOL
InChI Key BESPBINHRRCJFV-UHFFFAOYSA-N
4
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

669.6
MW (Da)
6.40
ALogP
9
HBA
3
HBD
124.2
PSA (Ų)
0.20
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H38Cl2N8O4
MW 669.61
Aromatic Rings 3
Heavy Atoms 46
NP-Likeness -1.01

Activity Summary

IC50 8 meas. best 8.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fibroblast growth factor receptor 4
CHEMBL3973
 IC50 8.42 8.42 3.8 2
Fibroblast growth factor receptor 2
CHEMBL4142
 IC50 6.64 6.64 228.0 2
Fibroblast growth factor receptor 1
CHEMBL3650
 IC50 6.61 6.61 244.0 2
Fibroblast growth factor receptor 3
CHEMBL2742
 IC50 6.51 6.51 311.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Fibroblast growth factor receptor 4 IC50 = 3.8 nM 8.42 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 4 IC50 = 3.8 nM 8.42 Determination of the Effect of the Compounds of the Present Invention Against FG... -
Fibroblast growth factor receptor 2 IC50 = 228.0 nM 6.64 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 2 IC50 = 228.0 nM 6.64 Determination of the Effect of the Compounds of the Present Invention Against FG... -
Fibroblast growth factor receptor 1 IC50 = 244.0 nM 6.61 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 1 IC50 = 244.0 nM 6.61 Determination of the Effect of the Compounds of the Present Invention Against FG... -
Fibroblast growth factor receptor 3 IC50 = 311.0 nM 6.51 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 3 IC50 = 311.0 nM 6.51 Determination of the Effect of the Compounds of the Present Invention Against FG... -

Data from ChEMBL 36 via Core Engine