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Compound Detail

CHEMBL5860515

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Cc1cc(-c2nnc(N)nc2-c2ccccc2F)cc(C(F)(F)F)n1

Basic Information

ChEMBL ID CHEMBL5860515
Phase Preclinical
Structure Type MOL
InChI Key PJTUHOGDEKJPQS-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

349.3
MW (Da)
3.65
ALogP
5
HBA
1
HBD
77.6
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H11F4N5
MW 349.29
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -1.31

Activity Summary

Ki 2 meas. best 8.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 8.26 8.26 5.5 1
Adenosine receptor A1
CHEMBL226
Ki 7.36 7.36 43.7 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine