Compound Detail
CHEMBL5868570
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C=CS(=O)(=O)Nc1cccc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1
Basic Information
| ChEMBL ID | CHEMBL5868570 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PVJAAGQGEGXGJN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
545.5
MW (Da)
6.56
ALogP
7
HBA
2
HBD
102.4
PSA (Ų)
0.26
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.26 | 7.26 | 55.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 55.0 | nM | 7.26 | FGFR-4 wild type assay: In each well of a 384-well plate, 0.5 ng/ul of wild type... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 550.0 | nM | 6.26 | FGFR-1 wild type assay: In each well of a 384-well plate, 0.1 ng/ul of wild type... | - |
Data from ChEMBL 36 via Core Engine