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Compound Detail

CHEMBL5924034

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COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(C(=O)N4CCN(C)CC4)c4ccccc34)c12

Basic Information

ChEMBL ID CHEMBL5924034
Phase Preclinical
Structure Type MOL
InChI Key QBWYZTMYCRAFMA-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

560.7
MW (Da)
5.91
ALogP
7
HBA
1
HBD
100.4
PSA (Ų)
0.29
QED
2
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H32N6O3
MW 560.66
Aromatic Rings 6
Heavy Atoms 42
NP-Likeness -0.76

Activity Summary

Ki 6 meas. best 8.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bromodomain-containing protein 3
CHEMBL1795186
Ki 8.89 8.445 1.3 2
Bromodomain-containing protein 2
CHEMBL1293289
Ki 8.39 8.32 4.1 3
Bromodomain-containing protein 4
CHEMBL1163125
Ki 7.82 7.82 15.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine